Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway
نویسندگان
چکیده
Open Access Poster presentation Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway Hideyuki Kinoshita*1, Koichiro Kuwahara1, Ryuji Inoue2, Motohiro Nishida3, Hitoshi Kurose3, Shigeki Kiyonaka4, Yasuo Mori4, Masaki Harada1, Masao Murakami1, Yasuaki Nakagawa1, Shinji Yasuno1, Satoru Usami1, Masataka Fujiwara1, Yoshihiro Kuwabara1, Takeya Minami1, Yuko Yamada1, Kenji Ueshima5 and Kazuwa Nakao1
منابع مشابه
Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.
RATIONALE Atrial and brain natriuretic peptides (ANP and BNP, respectively) exert antihypertrophic effects in the heart via their common receptor, guanylyl cyclase (GC)-A, which catalyzes the synthesis of cGMP, leading to activation of protein kinase (PK)G. Still, much of the network of molecular mediators via which ANP/BNP-GC-A signaling inhibit cardiac hypertrophy remains to be characterized....
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The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated.1–3 The successes of drugs that target the cGMP-signaling pathway (nitrovasodilators and PDE5 inhibitors [sildenafil, tadalafil, vardenafil]) have inspired interest in other cardiovascular benefits that might derive from a better understanding of this pathway.2,4–7 Elevation of cGMP in...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2009